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James Chen Selected Research

GS-9131

2/2008Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

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James Chen Research Topics

Disease

8Neoplasms (Cancer)
02/2022 - 03/2002
4Infections
01/2022 - 01/2018
3Tuberculosis (Tuberculoses)
12/2020 - 01/2017
2Leiomyosarcoma
01/2019 - 01/2018
2Glioblastoma (Glioblastoma Multiforme)
07/2015 - 06/2012
2Body Weight (Weight, Body)
02/2008 - 05/2007
1COVID-19
01/2022
1Colitis
01/2022
1Neurologic Manifestations (Neurological Manifestations)
01/2022
1Peripheral Nervous System Diseases (PNS Diseases)
01/2022
1Guillain-Barre Syndrome
01/2022
1Pneumonia (Pneumonitis)
12/2021
1Major Depressive Disorder (Major Depressive Disorders)
08/2021
1Autoimmune Diseases (Autoimmune Disease)
01/2021
1Alopecia Areata
01/2021
1Communicable Diseases (Infectious Diseases)
12/2020
1Rectal Neoplasms (Rectal Cancer)
12/2020
1Nausea
01/2020
1Staphylococcal Infections
01/2020
1Headache (Headaches)
01/2020
1Phobic Disorders (Phobia)
01/2020
1Wounds and Injuries (Trauma)
12/2018
1Skin Diseases (Skin Disease)
12/2018
1Melanoma (Melanoma, Malignant)
01/2018
1Dental Caries (Decay, Dental)
01/2018
1Hemorrhage
01/2018
1Renal Insufficiency (Renal Failure)
01/2018
1Sarcoma (Soft Tissue Sarcoma)
01/2018
1Hypoxia (Hypoxemia)
11/2017
1Parkinson Disease (Parkinson's Disease)
11/2017
1Prostatic Neoplasms (Prostate Cancer)
01/2017
1Superinfection
01/2017
1Neuroinflammatory Diseases
09/2016
1Inflammation (Inflammations)
09/2016
1Brain Injuries (Brain Injury)
09/2016
1Endoleak
09/2015
1Aneurysm (Aneurysms)
09/2015
1Paralysis (Palsy)
11/2012
1Central Nervous System Vascular Malformations (Dural Arteriovenous Fistula)
11/2012
1Brain Neoplasms (Brain Tumor)
06/2012
1Left Ventricular Dysfunction
04/2012
1Coronary Artery Disease (Coronary Atherosclerosis)
04/2012
1Heart Failure
04/2012
1Breast Neoplasms (Breast Cancer)
06/2010

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
12/2018 - 03/2002
2FidaxomicinIBA
01/2022 - 01/2018
2Biological ProductsIBA
01/2021 - 01/2017
2mocetinostatIBA
01/2019 - 01/2018
2GemcitabineFDA Link
01/2019 - 01/2018
2DNA-Directed RNA Polymerases (RNA Polymerase)IBA
01/2018 - 01/2017
2Proteins (Proteins, Gene)FDA Link
01/2018 - 06/2010
1AutoantibodiesIBA
01/2022
1AntibodiesIBA
01/2022
1Immunoglobulin G (IgG)IBA
01/2022
1Interleukin-10 (Interleukin 10)IBA
01/2022
1Amiodarone (Amiodarona)FDA LinkGeneric
12/2021
1Remifentanil (Ultiva)FDA Link
08/2021
1Hallucinogens (Psychedelics)IBA
08/2021
1KetamineFDA LinkGeneric
08/2021
1InterferonsIBA
01/2021
1CytokinesIBA
01/2021
1Rifampin (Rifampicin)FDA LinkGeneric
12/2020
1Acyl Carrier ProteinIBA
01/2020
1Fatty Acids (Saturated Fatty Acids)IBA
01/2020
1ProdrugsIBA
01/2020
1VancomycinFDA LinkGeneric
01/2020
1Oxidoreductases (Dehydrogenase)IBA
01/2020
1Linezolid (Zyvox)FDA Link
01/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1Analgesics (Analgesic Drugs)IBA
01/2020
1afabicinIBA
01/2020
1omega-Chloroacetophenone (Mace)IBA
01/2018
1GDC-0575IBA
01/2018
1Histone Deacetylase InhibitorsIBA
01/2018
1HoloenzymesIBA
01/2018
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2017
116S Ribosomal RNAIBA
01/2017
1DNA (Deoxyribonucleic Acid)IBA
01/2017
1LipopolysaccharidesIBA
09/2016
1Sirtuin 2IBA
09/2016
1Small Interfering RNA (siRNA)IBA
09/2016
1Biomarkers (Surrogate Marker)IBA
07/2015
1ethylene-vinyl alcohol copolymerIBA
11/2012
1BI 2536IBA
06/2012
1Polo-Like Kinase 1IBA
06/2012
1Diphosphates (Pyrophosphates)IBA
02/2008
1GS-9148IBA
02/2008
1GS-9131IBA
02/2008

Therapy/Procedure

9Therapeutics
12/2020 - 03/2002
3Drug Therapy (Chemotherapy)
12/2020 - 07/2015
2Lasers (Laser)
11/2010 - 03/2002
1Free Tissue Flaps
02/2022
1Personal Protective Equipment
01/2022
1Mechanical Ventilators (Ventilator)
01/2022
1Radiotherapy
12/2020
1Endovascular Aneurysm Repair
09/2015
1Endovascular Procedures
09/2015
1Cell- and Tissue-Based Therapy (Cell Therapy)
04/2012
1Injections
04/2012
1Oral Administration
02/2008